Making use of single-molecule optical and AFM imaging and drive-spectroscopy approaches, we seek out to unravel the mechanistic elements of the structure and dynamics of chromosomes. Our exploration passions include:
But how can morality, the dignity with the human being, my encounter of the indicating of existence, adhere to from the motion of atoms? A purely naturalistic viewpoint fails in this article; a Christian point of view, I believe, is a much more acceptable approach to interpret these aspects of fact.’
[Laughs] ‘It absolutely was surely an incredible possibility! At enough time, I used to be effectively conscious that it could go Incorrect and that I could come to be significantly less profitable, but I just overlooked that. Curiosity has often been my strongest driving power. And fortuitously it all labored out.’
A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola
That may be a dream of mine and we set to operate with a tasty dose of naivety. This is often something that will most likely generate breathtaking brings about the lengthier expression, but that doesn't matter. You should not only want to work to the questions of tomorrow, but additionally about the thoughts from the day soon after tomorrow.’
Our research ranges from the biophysics of DNA to artificial cells and further than. Be sure to take a look underneath with the spectrum of our recent initiatives.
We use nanofabricated microfluidic structures to sample spatial boundaries for microbes and biomimetic vesicles with reconstituted protein networks which evaluate the basic position of spatial confinement with the molecular and cellular degree. Our tasks consist of the following:
Instance (one) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is proven in grey, the rim of the pore is highlighted in purple, and a 3D rendering on the movement from the DNA rod is exhibited.
What if, as opposed to working with standard prime-down silicon electronics, transistors can be constructed from https://www.ceesdekker.net the bottom up working with one organic molecules since the switching things? This idea, which became The idea of currently’s field of molecular electronics, initial emerged while in the seventies.
Resolving the phase dimension in condensin-pushed DNA loop extrusion identifies ATP binding as being the phase-generating system
‘The concept that There may be this kind of factor for a beginning, an enormous bang, is by now a fascinating signpost to contemplate that there was a creator. But extra usually, and on the basis of pure rationality, I also arrive in a Christian interpretation of reality. An atheistic worldview is actually a naturalistic worldview: basically, you can find only atoms and purely natural forces that we will measure.
2006, 1st demonstration of molecular sorting inside of a lab on a chip making use of biomotors; discovery of nanobubbles in solid-state nanopores; and 1st estimate of electrokinetic Electricity conversion in a nanofluidic channel
Visualization of unstained DNA nanostructures with Innovative in-concentration transmission electron microscopy procedures
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and solitary-molecule experiments